Dihydroorotate dehydrogenases
نویسندگان
چکیده
منابع مشابه
Alcohol dehydrogenases and aldehyde dehydrogenases.
T h e structure, function and evolution of alcohol dehydrogenases and aldehyde dehydrogenases have been studied for several years. Recent progress o n these aspects has been considerable and allows extensive conclusions to be drawn about the relationships and properties of these enzymes. Further aspects have also become available for study, such as the regulation of enzyme expression and the an...
متن کاملDihydroorotate dehydrogenase in liver and Morris hepatomas.
Dihydroorotate dehydrogenase (DHODH) activity in the 3683, 3924A, 7288C, and 5123D Morris hepatomas was one-half that of normal rat liver. However, the DHODH activity in Morris hepatoma 7800 was the same as that of rat liver. No correlation existed between the activities of DHODH and the rates of growth of the hepatomas. The Km's of the DHODH of the hepatomas ranged from 2.5 to 11.5X IO"5 M and...
متن کاملAlcohol dehydrogenases.
9. Doonan, S., Martini, F., Angelaccio, S., Pascarella, S., Barra, D. & Bossa, F. ( 1986) J. Moi. Evol. 23, 328-335 McAllister-Henn, L. ( 1988) Trends Biocherrr. .ki . 13, 1781 8 1 Doyle, J. M. (1988) Ph.D. Thesis, National University of Ireland Martini, F., Angelaccio, S., Barra, D., Pascarella, S., Maras, B., Doonan. S. & Bossa, F. (1985) Hiochirn. Hiophys. Actcr 832, 46-5 I Lipman. D. J . & ...
متن کاملBiosynthetic dihydroorotate dehydrogenase from Lactobacillus bulgaricus.
This paper describes the first detailed study on a dihydroorotate dehydrogenase involved in pyrimidine biosynthesis. In most organisms the enzyme is membrane-bound; however, a soluble dihydroorotate dehydrogenase was produced in relatively high levels when the anaerobe, Lactobacillus bulgaricus, was released from repression. The enzyme was purified 213-fold over derepressed levels with a 39% re...
متن کاملCrystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase from Y strain.
Trypanosoma cruzi is the etiological agent of Chagas' disease, a pathogenesis that affects millions of people in Latin America. Here, we report the crystal structure of dihydroorotate dehydrogenase (DHODH) from T. cruzi strain Y solved at 2.2A resolution. DHODH is a flavin mononucleotide containing enzyme, which catalyses the oxidation of l-dihydroorotate to orotate, the fourth step and only re...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2000
ISSN: 0108-7673
DOI: 10.1107/s010876730002554x